This research was conducted in a privet Farm located at West Mallawy Center-Minia Governorate, on 8-year-old Early Sweet grapevines in clay soil. To study the impact of foliar sprinkle with royal jelly and glutathione at various levels on Early Sweet grapevines. The results indicated that, the application of glutathione considerably enhanced the yield, cluster parameters, physical and chemical of berries in comparison to the use of royal jelly. The vines that got three sprays of royal jelly (400 ppm) and glutathione (1000 ppm) showed the highest values of parameters except acidity and shot berries% were decreased, and there were no significant differences between the vines that were sprayed with the same combination at 200 and 500 ppm, respectively. The vines that were not treated yielded the lowest values. These findings were the same throughout two seasons. It could be concluded that using middle concentration for both royal jelly and glutathione was the most effective treatments.