Developing novel biomaterials for tissue engineering applications represents a pivotal frontier in regenerative medicine, aiming to restore, maintain, or enhance tissue function. This endeavor involves the integration of materials science, biology, and engineering principles to design scaffolds that not only support cell growth and differentiation but also mimic the native extracellular matrix's biomechanical and biochemical properties. The evolution of these biomaterials encompasses natural, synthetic, and hybrid polymers engineered at nano- to macro-scales to achieve optimal biocompatibility, biodegradability, and functionalization.