Salinity is one of the most crucial variables that limits crop productivity and quality. A field experiment was conducted in 2020/2021 and 2021/2022 to evaluate the efficiency of foliar application of arginine on reducing the harmful effects of saline irrigation water on anise plants. Anise plants were irrigated with various water salinity levels 1664, 2000, 2500, 3000 and 3500 ppm, the plant were sprayed with different rates of arginine i.e. 0, 100, 200 and 300 ppm. Salinity treatments decreased growth characteristics, fruits yield and nutrient contents. Salinity promoted the accumulation of volatile oil and its major component (Anethole). Spray application of arginine at rate 100 ppm was less effective on growth characteristics, fruits and oil yield under high salinity levels (3000 and 3500 ppm). However, the foliar application of arginine at rate 300 ppm resulted in positive increases in growth, fruits yield, essential oil yield and chemical constituents of anise under different saline irrigation levels, subsequently reduced the harmful effect of salinity.