The potential efficiency of different compost and N bio-inoculates combinations treatments to partial replacement of N mineral fertilizer in early sweet vineyard fertilization programs during three successive seasons (2019, 2020 and 2021) were conducted in this present investigation. According to the obtained data, it was generally found that mixing low doses (50 and 25%) of recommended dose of N mineral fertilizer with different compost and N bio-inoculates combinations increased significantly vegetative growth, yield and quality of early sweet vineyards during all studied seasons. The highest values of nitrate and nitrite contents in berries were found in vines treated with the recommended dose of N mineral fertilizer (100%NMF) alone, while the lowest and best values were gained from 100% compost combined with the three N bio-inoculates (AZO1, AZO2 and AZO3) treatments. The 50% N mineral fertilizer combined with 50% compost + AZO2 treatment gave the highest values of almost all studied traits during all tested seasons as compared with using recommended dose (100% NMF) alone. Finally, it could be concluded that to improve growth, yield and quality of early sweet vineyard and in the same time overcoming the actual hazards of N mineral fertilizers application, it might be recommended that to use a little dose of N mineral fertilizer combined with compost and N bio-fertilizers or using compost supplemented with N bio-fertilizers in grape fertilization programs.