This study was achieved during the two successive seasons 2017 and 2018. The experiment was conducted at private farm in Talha village, Minia Governorate (240 km southern Cairo city) – Egypt. The main target of this study was examining the effect of spraying of salicylic acid (SA) at 0, 1000, 2000 and 3000 ppm or/and chitosan at 0, 500, 1000 and 2000 ppm on leaves mineral content, yield, beery physical properties and beery chemical characteristics of Flame Seedless grapevines (Vitis vinifera L.) grown in heavy clay soil. Increasing chitosan or/and salicylic acid concentrations resulted in a gradual and significant promotion in leaves mineral contents, yield (kg/vine and number of clusters/vine), berry physical and chemical. However, no significant differences were observed neither between the two highest concentrations of chitosan (1000 and
2000 ppm) nor between the two highest concentrations of salicylic acid (2000 and 3000 ppm). The combined application of chitosan and salicylic acid was significantly preferable than using each martial alone in this respect. Furthermore, the vines received the two higher concentrations from chitosan (2000 ppm) and salicylic acid (3000ppm) gave the higher value in most studied parameters. However, no significant differences were observed between the two highest combined concentrations of chitosan and salicylic acid (2000 ppm chitosan + 3000 ppm salicylic acid) and (1000 ppm chitosan + 2000 ppm salicylic acid).