Under green house, the Population density of Aphis gossypii on cantaloupe plants recorded two peaks on May 9^th and 23^th with 1409 and 1561 individuals/ 10 leaves in season 2022, while one highest peak, on 16^th May with 1650 individuals/ 10 leaves in season 2023. Parasitism status of Aphidius colemani and Lysiphlebus fabarum varied from 1.49% on 25 April to 35.79% on 9^th of May with seasonal parasitism 2023 in 2022 and ranged between 0.73% on 25^th of April and 30.06% on 16^th of May with seasonal parasitism 16.57% in 2023. Acetamiprid, imidacloprid, imidacloprid + abamectin, jojoba oil, orange oil and thiamethoxam + abamectin compounds were tested to control aphids during two seasons. Imidacloprid recorded the highest reduction with all average 97.88 ±1.15 and 97.39 ±1.15 in the first and second season respectively. the highest mean reduction of emergence of the two-parasites caused by thiamethoxam + abamectin by 16.92% followed by Imidacloprid with 16.87%. While the least toxicity to emergence of the parasitoids recorded with jojoba oil 0.0% followed by orange oil 1.93% in season 2022, while in season 2023, the higher parasitoid reduction caused by acetamiprid 18.05% followed by Imidacloprid 17.69% and thiamethoxam + abamectin 17.53%. Chlorophyll content increased with treatment jojoba oil followed by Imidacloprid by 47.91 and 44.73 unit in the first season and Thiamethoxam with abamectin lead to the highest content by 44.05 unit in the leaves followed by jojoba oil with 43.65 unit. The least treatment was Imidacloprid + abamectin with 39.55 unit compared with control treatment 40.43 unit. Treatment Thiamethoxam + abamectin recorded the highest content of carbohydrates (48.43) compared with control (47.71). Treatments of insecticides led to increase of protein, fats and total lipid compared with control. Also, Antioxidant enzymes activity in cantaloupe leaves were found to be increased in the treatment of insecticides compared with control.