This study was carries out during 2020 and 2021 seasons for elucidating the effect of single and combined during foliar applications the antioxidant glutathione at 250 to 1000 ppm and Royal Jelly at 100 to 400 ppm three times after hand pollination, just after fruit setting and two months later on percentage of Initial fruit setting, the yield and fruit quality of Ferehy date palms grown under Siwa Oasis conditions. Foliar application three times with Royal Jelly at 100 to 400 ppm and /or the antioxidant glutathione at 250 to 1000 ppm had considerable promotion on initial fruit setting % and yield as well as physical and chemical characteristics of fruits over the control treatment. The promotion was associated with increasing the concentrations of Royal Jelly and glutathione. For promoting the yield and fruit quality of Ferehy date palms grown under Siwa Oasis conditions it is necessary for spraying a mixture of the antioxidant glutathione at 1000 ppm and Royal Jelly at 400 ppm three times after hand pollination, just after fruit setting and two months later.