This research was executed during two consecutive years (2019 and 2020) in a specific vine at El-Deer hamlet, Aga Center, Dakahlia region, Egypt. King Ruby grapevines aged 6 years were used in the experiment. The vines were trained to a quadrilateral cordon using a double-T support system and were cultivated in a clay soil with surface irrigation. Brassinosteroid at rate (2, 4, and 6 ppm) and methionine at rate (200, 400, and 600 ppm) were applied to the vine three times: at the commencement of growth, after flowering stage, and at veraison stage .The results showed that spraying brassinosteroid and methionine improved vegetative growth and total free amino  acids in the leaves, as well as percentages of nitrogen, phosphor and potassium in leaf petioles, yield per vine, cluster weight, cluster length, number of berries in a cluster, hundred berry weight, berry firmness, chemical properties of berries and total phenols in berries. The best data in terms to vegetative growth, yield per vine, and berry standard of the King Ruby grapevine cultivar were acquired when vines were foliar with brassinosteroid at a rate of 6 ppm.