Nanofertilization is a promising new method that could increase crop yields while decreasing the use of pesticides. Nanomaterials are extremely reactive because of their small size and large surface area. Several questions have been raised about the compatibility and contrast of these materials. Concerns have been expressed about the safety of farm workers using these products. This includes not only people who are exposed when nano fertilizers are made, but also people who are exposed when they are used in the field. While nano fertilizers may have some useful applications, further study is needed to establish how best to apply them and how much each plant or crop needs. Soil and biological systems can become more polluted at a faster rate due to the use of nanotechnology. So, we have an immediate duty to stop the harm that nano-fertilizers could do to people and the environment if they are not used correctly. With this review, we intend to address several concerns regarding the use of nano fertilizers. The appropriate usage of these chemicals requires substantial knowledge and specialized investigations before their application in agriculture to minimize their harmful effects on human health and the environment.